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Optimized arylomycins are a new class of Gram-negative antibiotics

Optimized arylomycins are a new class of Gram-negative antibiotics

Optimized arylomycins are a new class of Gram-negative antibiotics, Published online: 12 September 2018; doi:10.1038/s41586-018-0483-6

Chemical optimization of arylomycins results in an inhibitor of bacterial type I signal peptidase that shows activity both against multidrug-resistant clinical isolates of Gram-negative bacteria in vitro and in several in vivo infection models.

Read more http://feeds.nature.com/~r/nature/rss/current/~3/PS4V7PxbVdI/s41586-018-0483-6

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